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Multiphoton microscopy (MPM) is a non-invasive, high-resolution imaging method for looking at thick biological tissues. We use a femtosecond laser to develop MPM systems which can acquire two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) simultaneously. The MPM system is used to image cells and extracellular matrix in turbid tissues.
Through collaboration with the BC Cancer Research Center, our optical imaging systems and endomicroscopes will be applied to study lung and skin cancers. In vivo optical imaging will help doctors to detect cancer in its early stage.
This project aims to develop micro-endoscopes for in vivo intra-luminal tissue imaging. The design will use state-of-the-art techniques such as photonic crystal fibers, micro-optics, and MEMS scanners. The micro-endoscopes will enable high resolution, multimodality imaging of subsurface structures and compositions of internal organs.
This project aims to develop a multimodality optical imaging system by integrating multiphoton microscopy (MPM) with optical coherence tomography (OCT). MPM is sensitive to cells and extracellular matrix, and OCT to structural interfaces and tissue layers. The system will acquire structural and functional imaging of tissues simultaneously.
Optical coherence tomography (OCT) utilizes techniques such as interferometry and coherence gating to obtain high-resolution tissue images. We develop OCT systems for biomedical and industrial applications.
This research project aims to develop an implantable, biocompatible, optical glucose monitor, which would have a tremendous health-care benefit, providing an improved glucose-monitoring tool for diabetics. It is based on semiconductor laser sources (VCSELs) at the ideal wavelength for optical glucose sensing.