Dr. Lagally’s group develops microtechnology for biological analysis, specifically focused on fabrication of integrated systems for molecular diagnostics. A typical device from their laboratory will involve a combination of materials, including microchannels etched into glass or silicon, polymer microvalves, and metal thin films for heating, temperature sensing, and as substrates for chemical modification of the various interfaces within the system. Such highly integrated systems promise to extend the range of diagnostic abilities on the microscale by combining multiple measurements on many types of analytes (nucleic acids, proteins, metabolites) in order to build up a comprehensive picture of complex biological systems. In particular, his research group is initially focused on developing microsystems for affinity reagent selection and for detection, differentiation, and characterization of bacterial pathogens. Recent work toward the early detection of prostate cancer and microsystems for accomplishing this objective will also be discussed.