Label-Free Biosensing Using Cascaded Silicon-on-Insulator Micro-Racetrack Resonators Integrated With PDMS Microfluidic Channels
Publication Type:Conference Paper
Source:The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, Washington, USA (2011)
This paper demonstrates a label-free biosensing platform using Silicon-On-Insulator (SOI) micro-racetrack resonators,
cascaded such that multiple measurements can be made using a single input and output waveguide and therefore a single
detector. The devices are integrated with poly(dimethylsiloxane) microfluidic channels in order to characterize the devices’ sensing properties. Both bulk refractive index sensing using glycerin/water solutions and clinically-relevant biosensing using Human Factor IX and its corresponding antibody are characterized. Bulk sensitivities of 40 nm/RIU are achieved, and the devices are able to sense both the protein attachment during functionalization and the protein-antibody binding reaction.