Micro-endoscopes for in vivo tissue imaging
This project aims to develop micro-endoscopes for in vivo intra-luminal tissue imaging. The design will use state-of-the-art techniques such as photonic crystal fibers, micro-optics, and MEMS scanners. The micro-endoscopes will enable high resolution, multimodality imaging of subsurface structures and compositions of internal organs.
Optical imaging such as optical coherence tomography and multiphoton microscopy has been shown to be promising in detecting cancer in its early stages. When light shines on tissues, tissues can absorb, scatter, and reemit light due to the interaction of light with tissues. Both morphological and functional imaging can be obtained using optical imaging. Optical imaging has higher resolution and sensitivity than other imaging methods such as CT, MRI, and ultrasound. More importantly, light can be guided through tiny optical fibers to access tissue locations that are inaccessible by other imaging methods. For example, an optical-fiber based endoscope can be inserted into the human blood stream to access and image tumors in the brain.