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MEMS-based antibiofouling surfaces


Protein adsorption at the biomaterial-tissue interface is the first and critical event that initializes a cascade of host responses, including platelet activation, blood coagulation, and complement activation.1 Many approaches have been used to prevent such non-specific biological interactions.This research is investigating an engineering surface that uses micromechanical vibration to minimize protein adsorption.

Project Description

An anti-fouling mechanism based on the combined effects of electric field and shear stress has been demonstrated.
A lead zirconate titanate (PZT)
composite is used to generate an electric field and an acoustic streaming shear stress that increase nanomolecule desorption. In vitro characterization showed that (1) 58 ± 5.5% and 39 ± 5.2% of adsorbed bovine serum albumin (BSA) proteins can be effectively removed from fired silver and titanium coated PZT plate, respectively; and (2) 43 ± 9.7% of the anti-mouse immunoglobulin G (IgG) can be effectively removed from a fired silver coated PZT plate. Theoretical calculations on protein-surface interactions (van der Waals (VDW), electrostatic, and hydrophobic) and shear stress describe the mechanism for protein desorption from model surfaces. We have shown that the applied electric potential is the major contributor in reducing the adhesive force between protein and surface, and the desorbed protein is taken away by acoustic streaming shear stress. We strongly believe that the present method offers the possibility of minimizing nanomolecule adsorption without further surface treatment.

Faculty Supervisor(s)