Artificial Mechanical Skin Model
Development of an Artificial Mechanical Skin Model for Microneedle Insertion Profiling
With the ongoing development of a large variety of microneedles, characterizing microneedle-soft tissue interactions and mechanical testing of microneedles prior to their use in transdermal drug delivery emerge as major challenges. Microneedles must be tested against human skin to ensure that desired characteristics of microneedles (strength, resistance to irreversible deformation, required forces to penetrate the stratum corneum) are achieved for multiple insertions at a target depth in a repeatable manner. The accessibility of human skin samples for this purpose of microneedle testing is, in general, limited, and the mechanical properties of skin can vary from sample to sample. An alternative artificial mechanical human skin model would be valuable as a standard benchmark and for its availability.