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Dr. Karen Cheung

Dr. Karen Cheung

2332 Main Mall, Vancouver, BC Canada V6T 1Z4
Tel: +1 604.827.4114 Fax: +1 604.822.5949
http://www.ece.ubc.ca/~kcheung/

Email:

Education

B.S. 1998, University of California Berkeley
Ph.D. 2002, University of California Berkeley

Research Interests

bioMEMS,
implantable microelectrodes,
lab-on-a-chip devices,
microfluidics

Dr. Karen Cheung

Group Members:

Alumni:

Research Projects

Reversible cell trapping in microfluidic channels using hydrogelsReversible cell trapping in microfluidic channels using hydrogels
Biocompatible coatings for implantable polymer-based multielectrode arraysBiocompatible coatings for implantable polymer-based multielectrode arrays

Journal Publications

(Table View)
In Press
Michael C.W. Chen, Karen C. Cheung, "Hydrogel-based microfluidic cell culture", Biomaterials for MEMS: Pan Stanford Publishing, In Press  . Tagged XML BibTex
2016
Jonas Flueckiger, Shon Schmidt, Valentina Donzella, Ahmed Sherwali, Daniel M. Ratner, Lukas Chrostowski, Karen C. Cheung, "Sub-wavelength grating for enhanced ring resonator biosensor", Optics Express, 06/2016. Abstract Tagged XML BibTex
2015
Samantha M. Grist, Jonathan Schmok, Meng-Chi Andy Liu, Lukas Chrostowski, Karen C. Cheung, "Designing a microfluidic device with integrated ratiometric oxygen sensors for the long-term control and monitoring of chronic and cyclic hypoxia", Sensors, vol. 15, issue 8, pp. 20030-20052, 08/2015. Abstract Tagged XML BibTex
2014
Grist, Samantha Marie, Oyunerdene, Nominerdene, Flueckiger, Jonas, Kim, John, Wong, Philip C, Chrostowski, Lukas, Cheung, Karen C, "Fabrication and laser patterning of polystyrene optical oxygen sensor films for lab-on-a-chip applications", Analyst: Royal Society of Chemistry, 09/2014. Tagged XML BibTex
Shon Schmidt, Jonas Flueckiger, WenXuan Wu, Samantha M. Grist, Sahba Talebi Fard, Valentina Donzella, Pakapreud Khumwan, Emily R. Thompson, Qian Wang, Pavel Kulik, James Kirk, Karen C. Cheung, Lukas Chrostowski, Daniel Ratner, "Improving the performance of silicon photonic rings, disks, and Bragg gratings for use in label-free biosensing", Proc. of SPIE, vol. 9166, pp. 91660M-1--38, 08/2014. Abstract Tagged XML BibTex
2013
Xu Wang, Jonas Flueckiger, Shon Schmidt, Samantha Grist, Sahba Talebi Fard, James Kirk, Matt Doerfler, Karen C. Cheung, Daniel M. Ratner, Lukas Chrostowski, "A silicon photonic biosensor using phase-shifted Bragg gratings in slot waveguide", Journal Biophotonics, vol. 6, issue 10, pp. 821--828, 04/2013. Abstract Tagged XML BibTex
Samantha M. Grist, Shon A. Schmidt, Jonas Flueckiger, Valentina Donzella, Wei Shi, Sahba Talebi Fard, James T. Kirk, Daniel M. Ratner, Karen C. Cheung, Lukas Chrostowski, "Silicon photonic micro-disk resonators for label-free biosensing", Optics Express, vol. 21, issue 7: The Optical Society, pp. 7994–8006, 03/2013. Abstract Tagged XML BibTex
Talebi Fard, Sahba, Grist, Samantha M., Donzella, Valentina, Schmidt, Shon A., Flueckiger, Jonas, Wang, Xu, Shi, Wei, Millspaugh, Andrew, Webb, Mitchell, Ratner, Daniel M., Cheung, Karen C., Chrostowski, Lukas, "Label-free silicon photonic biosensors for use in clinical diagnostics", Proc. SPIE, Silicon Photonics VIII, vol. 8629, issue 862909, pp. 862909--14, 02/2013. Abstract Tagged XML BibTex
2012
S. M. Grist, L. Chrostowski, K. C. Cheung, "Thin Film Patterning using a Water-Soluble Etch Mask", 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 10/2012. Tagged XML BibTex
Daljeet Chahal, Ali Ahmadi, Karen C. Cheung, "Improving piezoelectric cell printing accuracy and reliability through neutral buoyancy of suspensions", Biotechnology and Bioengineering: Wiley Periodicals, Inc., 06/2012. Abstract Tagged XML BibTex
Lukas Chrostowski, Samantha Grist, Jonas Flueckiger, Wei Shi, Xu Wang, Eric Ouellet, Han Yun, Mitch Webb, Ben Nie, Zhen Liang, Karen C. Cheung, Shon A. Schmidt, Daniel M. Ratner, Nicolas A. F. Jaeger, "Silicon photonic resonator sensors and devices", Proceedings of SPIE Volume 8236; Laser Resonators, Microresonators, and Beam Control XIV, pp. 823620, 01/2012. Abstract Tagged XML BibTex
2011
Jonas Flueckiger, Vahid Bazargan, Boris Stoeber, Karen Cheung, "Characterization of postfabricated parylene C coatings inside PDMS microdevices", Sensors and Actuators B: Chemical , vol. 160, issue 1: Elsevier, pp. 864-874, 12/2011. Tagged XML BibTex
Jonas Flueckiger, Samantha M. Grist, Eric Ouellet, Lukas Chrostowski, Karen C. Cheung, "Label-Free Biosensing Using Cascaded Silicon-on-Insulator Micro-Racetrack Resonators Integrated With PDMS Microfluidic Channels", The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, Washington, USA, 10/2011. Abstract Tagged XML BibTex
Jonas Flueckiger, Samantha M. Grist, Gurpal Bisra, Lukas Chrostowski, Karen C. Cheung, "Cascaded silicon-on-insulator microring resonators for the detection of biomolecules in PDMS microfluidic channels", Proc. SPIE, Vol 7929; SPIE Microfluidics, BioMEMS, and Medical Microsystems IX, 01/2011. Tagged XML BibTex
2010
Samantha M. Grist, Lukas Chrostowski, Karen C. Cheung, "Optical Oxygen Sensors for Applications in Microfluidic Cell Culture", Sensors, vol. 10, issue 10: MDPI Publishing, Basel, Switzerland , pp. 9286-9316, 10/2010. Abstract Tagged XML BibTex
MCW Chen, M Gupta, KC Cheung, "Alginate-based microfluidic system for tumor spheroid formation and anticancer agent screening", Biomedical Microdevices, 03/2010. Tagged XML BibTex
Samantha M. Grist, Jonas Flueckiger, Jiali Yu, Wei Shi, Karen C. Cheung, Lukas Chrostowski, "Silicon-on-insulator resonators integrated with PDMS microfluidic channels for applications in biosensing", Pacific Center for Advanced Materials and Microstructures (PCAMM) 15th Annual Meeting, 2010  . Tagged XML BibTex
2009
J Flueckiger, FK Ko, KC Cheung, "Microfabricated Formaldehyde Gas Sensors", Sensors, vol. 9, issue 11, pp. 9196-9215, 11/2009. Tagged XML BibTex
J Flueckiger, KC Cheung, "Microfluidic System for Controlled Gelation of a Thermally Reversible Hydrogel", IEEE Transactions on Biomedical Circuits and Systems, vol. 3, issue 4, pp. 195-201, 08/2009. Tagged XML BibTex
MCW Chen, M Gupta, KC Cheung, "Hydrogel-Based Microfluidic System for Cell-Based Anticancer Agent Screening", 13th International Conference on Miniaturized Systrems for Chemistry and Life Sciences. Micro Total Analysis Systems (MicroTAS 2009), Jeju, South Korea, 01/11/2009. Tagged XML BibTex
Karen C. Cheung, "Thin-film microelectrode arrays for biomedical applications", Implantable Neural Prostheses: Techniques and Applications: Springer, pp. 157-190, 2009  . Tagged XML BibTex
2008
Jonas Flueckiger, Karen C. Cheung, "Locally Defined Thermally Reversible Hydrogel Formation in Microchannels", 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Micro Total Analysis Systems (MicroTAS 2008), 10/2008. Tagged XML BibTex
Michael C.W. Chen, Madhuja Gupta, Karen C. Cheung, "Hydrogel-based microfluidic systems for co-culture of cells", 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 08/2008. Tagged XML BibTex
Jonas Flueckiger, Karen C. Cheung, "Integrated microfluidic systems for cell culture and characterization", 14th IEEE International Mixed-Signals, Sensors, and Systems Test Workshop, 06/2008. Tagged XML BibTex
Mercanzini, André, Cheung, Karen, Buhl, Derek L., Boers, Marc, Maillard, Anne, Colin, Philippe, Bensadoun, Jean-Charles, Bertsch, Arnaud, Renaud, Philippe, "Demonstration of cortical recording using novel flexible polymer neural probes", Sensors and Actuators A: Physical, vol. 143, issue 1, 05/2008. Tagged XML BibTex
2007
Mercanzini, Andre, Karen C Cheung, Derek Buhl, Marc Boers, Anne Maillard, Philippe Colin, Jean-Charles Bensadoun, Arnaud Bertsch, Alan Carleton, Philippe Renaud, "Demonstration of Cortical Recording and Reduced Inflammatory Response Using Flexible Polymer Neural Probes", 20th IEEE International Conference on MEMS, Kobe, Japan, pp. 573-576, 2007  . Tagged XML BibTex
Karen C Cheung, Philippe Renaud, Heikki Tanila, Kaj Djupsund, "Flexible polyimide microelectrode array for in vivo recordings and current source density analysis", Biosensors and Bioelectronics, vol. 22, no. 8, pp. 1783-1790, 2007  . Tagged XML BibTex
Karen C Cheung, "Implantable Microscale Neural Interfaces", Biomedical Microdevices, 2007  . Tagged XML BibTex
2006
Karen C Cheung, Philippe Renaud, Heikki Tanila, Kaj Djupsund, "Flexible Microelectry Array: in vivo Recording and Tissue Reaction", 29th Canadian Medical and Biological Engineering Conference, Vancouver, Canada, 2006  . Tagged XML BibTex
Andre Mercanzini, Karen C Cheung, Arnaud Bertsch, Philippe Renaud, "The Lausanne Neuroprosthesis: A Flexible Polyimide Microelectrode for Acute and Chronic Cortical Recordings", The EPFL LATSIS Symposium 2006, Lausanne, Switzerland, pp. 109-110, 2006  . Tagged XML BibTex
Cheung, Karen C., Renaud, Philippe, "BioMEMS for medicine: On-chip cell characterization and implantable microelectrodes", Solid-State Electronics, vol. 50, no. 4, pp. 551-557, 2006  . Tagged XML BibTex
2005
Karen C Cheung, Philippe Renaud, "BioMEMS in Medicine: Diagnostic and Therapeutic Systems", 35th European Solid-State Device Research Conference, Grenoble, France, pp. 345-350, 2005  . Tagged XML BibTex
Karen C Cheung, Yinghui Zhong, Philippe Renaud, Ravi Bellamkonda, "Comparison of Tissue Reaction to Implanted Polyimide and Silicon Microelectrode Arrays", Biosurf VI - Tissue-Surface Interaction, Lausanne, Switzerland, 2005  . Tagged XML BibTex
Karen C. Cheung, Shady Gawad, Philippe Renaud, "Impedance spectroscopy flow cytometry: On-chip label-free cell differentiation", Cytometry Part A, vol. 65A, no. 2, pp. 124-132, 2005  . Tagged XML BibTex
2004
Shady Gawad, Karen C. Cheung, Urban Seger, Arnaud Bertsch, Philippe Renaud, "Dielectric spectroscopy in a micromachined flow cytometer: theoretical and practical considerations", Lab on a Chip, vol. 4, pp. 241-251, 2004  . Tagged XML BibTex
Karen C. Cheung, Shady Gawad, Philippe Renaud, "Impedance Spectroscopy Flow Cytometry: Parameters for Label-Free Cell Differentiation", 8th International Conference on Micro Total Analysis Systems, Malmö, Sweden, pp. 55-57, 2004  . Tagged XML BibTex
Shady Gawad, Karen C. Cheung, Philippe Renaud, "Impedance Spectroscopy Flow Cytometry: Model Validation", 8th International Conference on Micro Total Analysis Systems, Malmö, Sweden, pp. 58-60, 2004  . Tagged XML BibTex
Karen C. Cheung, Shady Gawad, Philippe Renaud, "Microfluidic Impedance Spectroscopy Flow Cytometer: Particle Size Calibration", 17th IEEE International Conference on MEMS, Maastricht, The Netherlands, pp. 343-346, 2004  . Tagged XML BibTex
2003
Cheung, Karen C., Djupsund, Kaj, Dan, Yang, Lee, Luke P, "Implantable multichannel electrode array based on SOI technology", Microelectromechanical Systems, Journal of, vol. 12, no. 2, pp. 179-184, 2003  . Tagged XML BibTex
Ionescu-Zanetti, Cristian, Cheung, Karen C., Lal, Ratneshwar, Lee, Luke P., "Simultaneous imaging of ionic conductivity and morphology of a microfluidic system", Journal of Applied Physics, vol. 93, no. 12: AIP, pp. 10134-10136, 2003  . Tagged XML BibTex
2002
Karen C. Cheung, Tim Kubow, Luke P Lee, "Individually Addressable Planar Patch Clamp Array", 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Madison, USA, pp. 72-76, 2002  . Tagged XML BibTex
Tim Kubow, Karen C. Cheung, Loren F Bentley, Luke P Lee, "Microfabricated Patch Clamp Array for Neural MEMS Applications", Materials Research Society Spring 2002 Meeting, San Francisco, USA, 2002  . Tagged XML BibTex
Karen C. Cheung, Yang-Kyu Choi, Tim Kubow, Luke P Lee, "Nanostructured Electrodes for Neural Chip Applications", 6th International Conference on Micro Total Analysis Systems, Nara, Japan, pp. 778-780, 2002  . Tagged XML BibTex
Karen C. Cheung, Yang-Kyu Choi, Tim Kubow, Luke P Lee, "Nanostructured Electrodes for Improved Neural Recording", Materials Research Society Spring 2002 Meeting, San Francisco, USA, 2002  . Tagged XML BibTex
2000
Karen C. Cheung, Gun Lee, Kaj Djupsund, Yang Dan, Luke P Lee, "A new neural probe using SOI wafers with topological interlocking mechanisms", 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Lyon, France, pp. 507-511, 2000  . Tagged XML BibTex
1999
Barth, Phillip W., McAllister, William H., Hoen, Storrs, Cheung, Karen C., Gas-flow management using capillary capture and thermal release, , no. 440834, USA, Agilent Technologies Inc., 1999  . Tagged XML BibTex
1997
Tejal A Desai, Karen C. Cheung, WH Chu, Mauro Ferrari, "In vitro immunoisolative properties of microfabricated biocapsules", 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, USA, pp. 2578-2581, 1997  . Tagged XML BibTex