%0 Journal Article %J Journal Biophotonics %D 2013 %T A silicon photonic biosensor using phase-shifted Bragg gratings in slot waveguide %A Wang, Xu %A Flueckiger, Jonas %A Schmidt, Shon %A Grist, Samantha %A Fard, Sahba Talebi %A Kirk, James %A Doerfler, Matt %A Cheung, Karen %A Ratner, Daniel %A Chrostowski, Lukas %K biosensor, silicon photonics,slot waveguide, Bragg grating, microfluidics, limit of detection %N 10 %P 821--828 %U http://onlinelibrary.wiley.com/doi/10.1002/jbio.201300012/abstract %V 6 %X We present a novel silicon photonic biosensor using phase-shifted Bragg gratings in a slot waveguide. The optical field is concentrated inside the slot region, leading to efficient light-matter interaction. The Bragg gratings are formed with sidewall corrugations on the outside of the waveguide, and a phase shift is introduced to create a sharp resonant peak within the stop band. We experimentally demonstrate a high sensitivity of 340 nm/RIU measured in salt solutions and a high quality factor of 1.5 10^{4}, enabling a low intrinsic limit of detection of 3 10^{?4} RIU. Furthermore, the silicon device was fabricated by a CMOS foundry, facilitating high-volume and low-cost production. Finally, we demonstrate the device's ability to interrogate specific biomolecular interactions, resulting in the first of its kind label-free biosensor. ( 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) %Z This is the pre-peer reviewed version of the following article: Wang, X., Flueckiger, J., Schmidt, S., Grist, S., Fard, S. T., Kirk, J., Doerfler, M., Cheung, K. C., Ratner, D. M. and Chrostowski, L. (2013), A silicon photonic biosensor using phase-shifted Bragg gratings in slot waveguide. J. Biophoton.. doi: 10.1002/jbio.201300012, which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/jbio.201300012/abstract]. http://www.mina.ubc.ca/files/JBP-pre-peer-review.pdf %8 04/2013